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Wed 4 Apr 2007 01:07 PM

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New type of stent shows promise

A new study called the ABSORB Trial, involving researchers from the Erasmus Medical Center in the Netherlands, has evaluated the Bioabsorbable Everolimus-Eluting Coronary Stent System (BVS EECSS).

A new study called the ABSORB Trial, involving researchers from the Erasmus Medical Center in the Netherlands, has evaluated the Bioabsorbable Everolimus-Eluting Coronary Stent System (BVS EECSS). The BVS stent has a bioabsorbable structure made of polylactic acid - a biodegradable polyester derived from lactic acid - and a coating that controls the release of the drug everolimus - an immunosuppressant to prevent rejection.

While metallic drug-eluting stents reside permanently in the treated artery, the BVS stent is designed to be fully absorbed and slowly metabolised by the artery, leaving a healed natural vessel behind.

Researchers enrolled 30 patients at four clinical sites in Europe and New Zealand in the ABSORB Trial. Each patient had one coronary artery lesion and was treated with the BVS stent. Researchers evaluated device success (efficacy), procedural success (ease of deployment and safety), major adverse cardiac events (MACE) and stent thrombosis at 30 and 180 days.

At 30 days, device and procedural success was extremely high - 93.5 and 100% respectively - and no patients experienced MACE or stent thrombosis. At 180 days, rates of MACE continued to be low at 3.3% (one patient with a non-Q wave myocardial infarction) and there were no cases of stent thromboses.

"Early results at one and six months indicate that the BVS stent is safe, effective and easy to deploy," said Patrick Serruys, M.D., of the Erasmus Medical Center and lead author of the study. "We will continue to follow these patients to determine the long-term safety and performance of the stent, and if it eliminates any of the issues associated with metal stents."

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