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Fri 11 Jul 2008 07:22 PM

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Study of Arabic genetics aids autism research

Over 100 families from across Arabia volunteer for research into genetic influences on autism.

Research on large Middle Eastern families has helped scientists pinpoint six new genes implicated in autism, a new study reveals.

The research "strongly supports the emerging idea that autism stems from disruptions in the brain's ability to form new connections in response to experience - consistent with autism's onset during the first year of life when many of these connections are normally made," a team led by researchers at Children's Hospital Boston and members of the Autism Consortium said.

In traditional Arab societies, cousins commonly wed, making it more likely that rare mutations will be expressed, the team said in study published in Science.

And Middle Eastern families typically have significantly more children than those in the west, which makes them relatively more useful in genetic studies.

The Homozygosity Mapping Collaborative for Autism recruited 104 families from across the Arabic Middle East, Turkey and Pakistan, in which there was a high incidence of autism; 88 of the families included cousin marriages.

Researchers looked to compare the DNA of relatives with and without autism and for recessive mutations, where the disease is seen only when a child has two copies of a particular gene.

"We check each set of chromosomes from beginning to end looking for one place where the child has two identical pieces of DNA on both chromosomes," said Walsh.

"Eventually we find a spot where all affected children have two identical chunks of DNA, and where unaffected children have something different."

Slightly more than six percent of the 88 families had rare inherited deletions in DNA regions linked to autism, the research found. The 88 families were from eight countries: Jordan, Saudi Arabia, Kuwait, Oman, Pakistan, Qatar, Turkey and the United Arab Emirates.

"Interestingly, not all the affected genes were actually deleted, but only prevented from turning on, offering hope that therapies could be developed to reactivate the genes," the researchers added in their statement.

Many genes can contribute to autism, researchers say, which makes it impossible to search for just one critical gene that causes the disease, as with cystic fibrosis or Huntington's disease.

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